AAVLife

company

About

AAVLife is a privately held company dedicated to advancing gene therapy for rare diseases.

  • 1 - 10

Details

Last Funding Type
Series A
Last Funding Money Raised
$12M
Industries
Genetics,Health Care,Information Technology,Medical,Therapeutics
Founded date
Jan 1, 2014
Number Of Employee
1 - 10
Operating Status
Active

AAVLife's lead indication is for Friedreich’s Ataxia Cardiomyopathy. Their program is based on the successful use of a gene-therapy approach in a mouse model developed to mimic the gene defect and cardiac symptoms of Friedreich’s Ataxia. The approach made use of an adeno-associated virus (AAV) to introduce a normal gene into cardiac tissue. The therapy restored cardiac function and reversed pathological heart enlargement in mice that had already progressed to heart failure.

AAVLife has progressed research of this gene-therapy approach to inform decisions about dosing and route of administration to be used in a clinical trial. The company will be conferring with regulatory authorities about toxicity-study requirements and clinical-trial design. The goal is to commence a clinical trial in 2015 to evaluate gene therapy for heart disease associated with Friedreich’s Ataxia. An observational study will be initiated in 2014 as a run-up to treating patients in a Phase I/II study.

Friedreich’s Ataxia is a life-threatening disorder caused by a genetic mutation that results in progressive neurologic and cardiac symptoms typically first appearing in childhood or during the teenage years. Cardiac disease accounts for the majority of deaths due to Friedreich’s Ataxia, with death usually occuring in early adulthood.

They are passionate in their quest to serve patients and value their relationship with patient communities and the organizations that serve them.

Funding Rounds

Number of Funding Rounds
Total Funding Amount
1
$12M
AAVLife has raised a total of $12M in funding over 2 rounds. Their latest funding was raised on Apr 15, 2014 from a Series A round.
Announced Date Round Money Raised Number of Investors Lead Investors Post Valuation
Apr 15, 2014 Series A $12M 2 Versant Ventures Detail

Investors

Number of Lead Investors
Number of Investors
1
2
AAVLife is funded by 2 investors. Versant Ventures and Inserm Transfert Initiative are the most recent investors.
Investor Name Lead Investor Funding Round
Versant Ventures Yes Series A
Inserm Transfert Initiative Series A