Gwill led the firm's east coast investment activities, managed LP relations and oversaw portfolio management for the first five Lighthouse investment partnerships. She continues to manage Lighthouse's fourth and fifth investment partnerships in conjunction with the firm's partners.While at Lighthouse Gwill sponsored the firm's investments in NxStage Medical, Millennium Pharmaceuticals, DataSage, Sirocco Systems, Corvis, Triton, Ontogeny, StorageNetworks, and Bolt Media. Prior to co-founding Lighthouse in June 1994, Gwill was a Senior Vice President with Comdisco Ventures where she established and managed East Coast investment activities. While at Comdisco, she led the firm's investments in over 50 companies, primarily in the biotechnology and communications equipment areas including Human Genome Sciences, Millennium Pharmaceuticals, Vertex Pharmaceuticals, Cascade Communications, Appex, and Brooktrout Technologies.