Overview

Gender

male

Dr. Qu is an Associate Professor in the Pharmaceutical Sciences Department of SUNY-Buffalo. His interests are in Proteomics and Pharmaceutical Analysis, and their applications in pharmaceutical and clinical research.

His research programs in the proteomic field involve i) high-resolution and large-scale expression profiling of pathological proteomes (e.g. for cardiovascular diseases, colon cancer and infectious diseases, HIV, COPD, etc) for the discovery of disease/drug-effect biomarkers by gel-free LC/MS methods; ii) Sensitive identification, localization and quantification of post-translational modifications in complex proteomes, with the emphases on arginine methylation and phosphorylation.

Novel anti-PTM-peptides capture procedure and alternating collision induced dissociation (CID)/electron transferring dissociation (ETD) are employed to obtain abundant PTM information; iii) targeted quantification of protein drugs and biomarkers for clinical study.

Dr. Qu’s lab possesses many state-of-the-art LC/MS instruments, including a high resolution/accuracy LTQ/Orbitrap ELITE with ETD, a highly sensitive TSQ Quantum Ultra EMR triple-quadrupole instrument, ultra-high pressure nano-LC systems, and HPLC instruments for pre-fraction and ion chromatography. A number of key analytical advances have been developed by his lab that greatly enhanced the drug discovery and development processes.

He has been actively collaborating with Kinex since 2010 using cutting-edge proteomics and LC/MS techniques for in-depth investigation of the mechanisms of actions of Kinex compounds.